Niclosamide
Insecticide and Molluscicide
Niclosamide NOMENCLATURE
Common name niclosamide (BSI, E-ISO, (m) F-ISO, BAN, Germany (for veterinary use))
IUPAC name 2', 5-dichloro-4'-nitrosalicylanilide
Chemical Abstracts name 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
CAS RN [50-65-7]
Niclosamide PHYSICAL CHEMISTRY
Mol. Wt. 327.1
M. F. C13H8Cl2N2O4
Form Almost colourless crystals.
M. P. 230 º C
V. P. <1 mPa (20 º C)
KOW logP = 1 (pH 9.6)
Solubility In water 1.6 (pH 6.4), 110 (pH 9.1) (both in mg/l, 20 º C). Soluble in common organic solvents such as ethanol
Stability Hydrolysed in aqueous solution, DT50 (20 º C) c. 7 d (pH 6.9), 18.8 d (pH 13.3). Stable to heat. Decomposes under u. V. Irradiation. Hydrolysed by concentrated acid or alkali.
Niclosamide 25%EC APPLICATIONS
Niclosamide 25%EC Mode of action
Molluscicide with respiratory and stomach action.
Niclosamide 25%EC Uses
Control of golden apple snail in rice. Control of schistosomiasis and fascioliasis in man by killing fresh-water snails which act as intermediate hosts. Also used for veterinary control of tapeworm infestations.
Compatibility Incompatible with acidic materials.