Niclosamide
Insecticide and Molluscicide
Niclosamide NOMENCLATURE
Common name niclosamide (BSI, E-ISO, (m) F-ISO, BAN, Germany (for veterinary use))
IUPAC name 2', 5-dichloro-4'-nitrosalicylanilide
Chemical Abstracts name 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
CAS RN [50-65-7]
Niclosamide PHYSICAL CHEMISTRY
Mol. Wt. 327.1
M. F. C13H8Cl2N2O4
Form Almost colourless crystals.
M. P. 230 º C
V. P. <1 mPa (20 º C)
KOW logP = 1 (pH 9.6)
Solubility In water 1.6 (pH 6.4), 110 (pH 9.1) (both in mg/l, 20 º C). Soluble in common organic solvents such as ethanol and diethyl ether.
Stability Hydrolysed in aqueous solution, DT50 (20 º C) c. 7 d (pH 6.9), 18.8 d (pH 13.3). Stable to heat. Decomposes under u. V. Irradiation. Hydrolysed by concentrated acid or alkali.
Niclosamide 25%EC APPLICATIONS
Niclosamide 25%EC Mode of action
Molluscicide with respiratory and stomach action.
Niclosamide 25%EC Uses
Control of golden apple snail in rice. Control of schistosomiasis and fascioliasis in man by killing fresh-water snails which act as intermediate hosts. Also used for veterinary control of tapeworm infestations.
Compatibility Incompatible with acidic materials.
Niclosamide Selected tradenames
'Bayluscide' (EC250) (Bayer)
Niclosamide Formulation types
Niclosamide 25%EC
Niclosamide 50%WP